Use the lowest efficient dosage for that shortest length of time reliable with particular person patient remedy plans [see Warnings and Safety measures (5)]. Because the chance of overdose boosts as opioid doses maximize, reserve titration to higher doses of OXYCONTIN for patients in whom lower doses are insufficiently powerful and in whom the anticipated advantages of working with the next dose opioid Obviously outweigh the sizeable threats.

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The concomitant utilization of OXYCONTIN with all cytochrome P450 3A4 inhibitors may perhaps result in an increase in oxycodone plasma concentrations, which could enhance or extend adverse drug consequences and could cause probably deadly respiratory melancholy. Also, discontinuation of the concomitantly applied cytochrome P450 3A4 inducer may lead to an increase in oxycodone plasma concentration.

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Oxycodone hydrochloride tablets, USP 15 mg are equipped as environmentally friendly, round, biconvex tablets debossed with “A” over the remaining and “forty nine” here on the ideal website of the score on one facet and get more info plain on the other side.

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Sufferers ought to be encouraged to report episodes of breakthrough soreness and adverse encounters developing all through therapy. Individualization of dosage is vital to produce best use of this medication.

Conversion from Other Opioids to OXYCONTIN When OXYCONTIN therapy is initiated, discontinue all other opioid analgesics in addition to Those people utilised on an as required foundation for breakthrough soreness when acceptable.

While significant, lifetime-threatening, or lethal respiratory despair can manifest Anytime throughout the use of OXYCONTIN, the danger is best through the initiation of therapy or next a dosage boost.

Serotonin syndrome: Conditions of read more serotonin syndrome, a most likely daily life-threatening situation, have been described through concomitant use of opioids with serotonergic drugs.

A research of OXYCONTIN in individuals with hepatic impairment shown larger plasma concentrations than Individuals witnessed at equivalent doses in people with usual hepatic perform [see Scientific Pharmacology (12.

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Gender: Inhabitants pharmacokinetic analyses done during the clinical analyze support the lack of gender effect on the pharmacokinetics of oxycodone from oxycodone hydrochloride.